Derived from Astragalus membranaceus and enriched in Astragaloside IV, AST-4™ combines natural origin with targeted activity across biological pathways involved in skin longevity.

Rather than focusing on a single mechanism, it supports coordinated cellular functions associated with stress response, senescence control, autophagic balance and extracellular matrix renewal. This helps the skin maintain resilience and structural integrity over time.

Its activity has been investigated through in silico bioactivity mapping, targeted in vitro studies and clinical evaluation. The results connect molecular-level activity with visible performance, including increased radiance after one hour and measurable improvements in wrinkles and skin tone after 28 days.

Cellular Support for Visible Skin Longevity

Skin ageing is shaped not only by the passage of time, but also by how effectively cells respond to stress, clear damaged components and maintain structural proteins.

AST-4™ supports these connected processes through the Longevity-Driven Cellular Programming™ framework. In vitro results show activity across cellular resilience, senescence control, autophagic balance, ECM renewal, oxidative stress and pigmentation pathways.

In vitro Efficacy

• 142% increase in FOXO3 expression
• 166% increase in COL1A1 levels
• 36.88% reduction in p21 levels
• 41% reduction in LC3-II levels
• 84.85% reduction in MDA levels
• 81.82% tyrosinase inhibition

Immediate Radiance and Progressive Wrinkle Reduction

A placebo-controlled, single-blind split-face clinical study was conducted with 32 women aged 37–60 with Fitzpatrick skin phototypes III–IV, using a cream containing 0.3% AST-4™ twice daily.

After One Hour

• 18.09% increase in skin gloss

After 28 Days

• 10.04% reduction in nasolabial fold wrinkle area vs placebo
• 8.56% reduction in crow’s-feet wrinkle area vs placebo
• 11.11% improvement in skin radiance vs placebo
• 21.52% improvement in skin gloss vs placebo
• 6.38% reduction in melanin index vs placebo