CLOUDIN+™
Next Generation Barrier Care for Face and Body
Body skin deserves the same attention as facial skin. CLOUDIN+™ brings targeted botanical activity to advanced body care, combining barrier support with clinically assessed improvements in hydration, softness and visible redness-associated sensitivity.
CLOUDIN+™ supports complementary pathways involved in epidermal integrity, dermal structure and skin comfort. Its activity is evaluated through in vitro studies and placebo-controlled clinical assessments using a hand cream containing 2.0% CLOUDIN+™.
Adaptive Body Care: Beyond Hydration
Effective hydration depends on the skin’s ability to retain moisture and maintain its protective barrier.
CLOUDIN+™ supports skin through increased occludin protein levels, a marker associated with epidermal tight junction integrity. Complementary activity on Type I collagen, inflammatory IL-6 signaling and antioxidant capacity supports a multi-layer approach to skin resilience and comfort.
In vitro Efficacy
- 26.00% increase in occludin protein levels vs untreated control
- 25.20% increase in Type I collagen levels vs untreated control.
- 15.83% reduction in IL-6 levels vs TNF-α-stimulated control.
- 42.62% ABTS radical-scavenging activity.
CLOUDIN+™ is developed for skin comfort across generations
CLOUDIN+™ is clinically assessed in two placebo-controlled studies spanning Gen Z and Gen X. Evaluated at 2.0% in a hand cream, it provides immediate and progressive soothing benefits, supporting an age-inclusive approach to advanced body care.
- Soothing after 1 hour: 12.70 percentage points greater reduction in redness-associated skin sensitivity vs placebo in the Gen Z study.*
- Soothing after 5 days: 53.60 percentage points greater reduction in redness-associated skin sensitivity vs placebo in the mixed Gen Z and Gen X study.**
- Hydration after 28 days: 22.25% increase in skin moisture from baseline, compared with 10.81% for placebo in the Gen Z study.*
Sensitivity differences are expressed in percentage points. *p < 0.05; **p < 0.01 versus placebo.
HIGHLIGHTS
Age-Inclusive Body Care
Supports long-term skin comfort in hands exposed to daily stress in Gen Z and Gen X participants.
Body Barrier Resilience
Maintains barrier function in body skin under seasonal challenges and supports skin quality over time.
Occludin-Linked Barrier Function
Supports tight junction integrity and paracellular barrier regulation.
Moisture Retention Under Stress
Helps limit moisture loss caused by frequent washing and exposure.
Frequent-Use Ready
Suitable for leave-on and rinse-off hand and body formulations.
CHARACTERISTICS
INCI
Water, Glycerine, Aloe barbadensis Leaf Extract, Melissa officinalis Extract, Chamomilla recutitta Flower Extract, Potassium Sorbate, Sodium Benzoate, Citric Acid
Recommended Use Level
1.0% to 4.0%