CLOUDIN+™ is a barrier-strengthening active developed to support long-lasting moisture balance and skin comfort in hand and body care applications. It is designed for skin repeatedly exposed to washing, friction, temperature changes, and environmental stress.

At the core of its performance lies occludin-related barrier regulation. Occludin is a key protein involved in tight junction integrity, playing a central role in maintaining barrier function and controlling paracellular water loss. CLOUDIN+™ supports this junctional stability, helping the skin preserve barrier function and retain moisture more effectively under daily stress conditions.

Hands as the First Aging Surface

Hands are among the most exposed skin areas, yet often the least protected. Frequent washing, constant environmental exposure, mechanical stress, and temperature fluctuations continuously challenge the integrity of the hand skin barrier. 

Unlike facial skin, hands have limited sebaceous support and experience repeated disruption of tight junction organization throughout the day. Over time, this leads to impaired barrier function, increased moisture loss, reduced flexibility, and visible signs commonly associated with premature aging of the hands. By supporting occludin-related tight junction integrity, CLOUDIN+™ helps maintain proper cell–cell junction organization and paracellular barrier regulation. This targeted support helps hands better retain moisture and maintain functional stability despite cumulative daily stress.

Hand Longevity Starts with Barrier Function

Hand aging is driven less by time and more by exposure. Repeated cleansing, friction, and environmental challenges progressively weaken barrier function, making it increasingly difficult for the skin to regulate moisture and maintain structural balance. CLOUDIN+™ introduces a longevity-oriented approach to hand care by positioning barrier function as a prerequisite for long-term skin quality. Through occludin-related support of tight junction integrity, it helps sustain paracellular barrier regulation and reduce moisture loss over time.

Rather than offering short-term hydration alone, this barrier-centered strategy supports long-lasting skin comfort, improved flexibility, and a smoother appearance, contributing to healthier-looking hands with regular use.

Barrier Regulation for Body Skin Under Stress

The same mechanism benefits body skin exposed to seasonal dryness, temperature shifts, and environmental aggressors. By supporting junctional stability and barrier function, CLOUDIN+™ helps maintain moisture balance and skin comfort across larger skin areas.

Its adaptive profile makes it suitable for both leave-on and rinse-off formulations intended for frequent use, supporting barrier regulation without compromising sensory comfort.